An in vitro simulator for ventricular assist devices

02:453 years ago

Despite the positive outcomes of ventricular assist device (VAD) therapy, there are still some adverse events, such as suction, caused by the mismatch of the preload of the left ventricle and the flow of the pump. Ventricular suction can be due to multiple underlying pathophysiological conditions. However, the medical management of such patients is still not well defined. In order to analyse the potential of different therapeutic interventions to mitigate suction in different pathophysiological conditions, a suction module is embedded in a cardiovascular hybrid (hydraulic-computational) simulator. The suction module mimics the ventricular apex and its connection with a HeartWare HVAD system (Medtronic). With such a set-up, the medical management of different pathophysiological conditions can be evaluated, without the use of animals.

Also watch the video on the cardiovascular simulator used for this research: https://tpi.tv/watch/76

Contact: https://www.linkedin.com/in/maria-rocchi-9aa7b4162/

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EURL ECVAM

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EURL ECVAM

The EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) promotes and facilitates the use of non-animal methods in testing and research. It validates, disseminates and shares knowledge on the 3Rs (Replacement, Reduction and Refinement of animal experiments). In this video, Raffaella Corvi explains what EURL ECVAM does in the field of safety testing of chemicals while reducing laboratory animal testing. Watch the accessible version of the video here (https://audiovisual.ec.europa.eu/en/video/I-230374). ©European Union, 2021

02:336 months ago

Five simple tricks for making your own video for TPI.tv

Five simple tricks for making your own video for TPI.tv

This video shows you how to make a video yourself. It's really not that difficult! See also the submission page (https://tpi.tv/submit-a-video) for additional information.

01:234 years ago

Cultured human skin for burn research

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Cultured human skin for burn research

Burns are often accompanied by a dysregulated immune response, which can lead to systemic inflammation, impaired immunity, and excessive scarring. A deeper understanding of the mechanisms behind burns—where wound healing and inflammatory reactions are severely disrupted—holds the key to improving patient outcomes. Patrick Mulder, a postdoctoral researcher at the Burn Research Lab in Beverwijk, the Netherlands, works with his colleagues to develop animal-free skin models based on human cells and patient-derived tissues. Using these innovative, human-relevant models, he aims to provide greater insight into the body’s response to burns and studies the effects of existing and new treatments on wound healing. Click on the info button for the full version of the video.

00:295 days ago

An iPSC-derived blood-brain barrier to model neurodegeneration

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An iPSC-derived blood-brain barrier to model neurodegeneration

The blood-brain barrier is a layer of cells that protects our brain from harmful compounds. However, due to this tight barrier, many drugs to treat neurological diseases cannot enter the brain either. There are currently no good models to test these types of drugs. Henrique Nogueira Pinto is a PhD candidate at the Vrije Universiteit in Amsterdam. He is developing a blood-brain barrier model coupled to mini-brains. With this model, he aims to more reliably test how drugs can be transported over the blood-brain barrier and what their effect on the brain is. Click on the info button for the full version of the video. Click her (https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-022-00316-0#Sec3)e for a review of the current status of in vitro models for the blood-brain barrier.

01:055 days ago